UniOne® TR-FRET Human GSPT1/CRBN PROTAC Binding KIT Residue Detection Kit Michael Feigh

Michael Feigh

Background Secreted frizzled-related protein 5 (SFRP-5) is a protein encoded by the SFRP5 gene in humans

and ERK1/2

or pyruvate dehydrogenase E1 subunit alpha 1

UniOne® TR-FRET Human GSPT1/CRBN PROTAC Binding KIT Residue Detection Kit Michael FeighProduct Specification Host Human Stability & Storage 80 Background This kit utilizes Time ResolvedFluorescence Resonance Energy Transfer (TR FRET) technology to measure theinteraction between GSPT1 and CRBN mediated by the molecular glue CC 885 andtest compounds. This method provides a simple, rapid, and high throughputformat for detecting small molecules capable of mediating GSPT1 CRBNinteractions. As shown, the interaction betweenGSPT1 and CRBN is